Compatibility study of cashew and prosopis gums with some artemisinin derivatives
Emmanuel O. Olorunsola1,2*, Partap G. Bhatia3, Babajide A. Tytler2, Michael U. Adikwu4

1 Department of Pharmaceutics and Pharmaceutical Technology, University of Uyo, Uyo, Nigeria. 2 Department of Pharmaceutics and Pharmaceutical Microbiology, Ahmadu Bello University, Zaria, Nigeria. 3 Department of Pharmaceutics and Pharmaceutical Microbiology, Usmanu Danfodiyo University, Sokoto, Nigeria. 4 University of Abuja, Abuja, Nigeria.
*Corresponding author: Emmanuel O. Olorunsola ,Tel.: +2348035067306,E-mail: olorunsolaeo@yahoo.com.

ABSTRACT

Introduction: Drug – excipient compatibility study is important to pre-formulation and is carried out to ensure that there is no adverse interaction between the drug and any excipient. This study was aimed at investigating the compatibility of cashew gum (CSG) and prosopis gum (PRG) with artemether (ATM) and artesunate (ATS).

Methods: Interactions between each drug and each excipient were investigated by taking the differential scanning thermograms (DSC), the Fourier transform infrared (FTIR) spectra and X-ray diffraction (XRD) patterns of pure drugs, pure gums and drug/gum mixtures.

Results: The presence of cashew gum and prosopis gum had similar effects of reducing the melting point and increasing the recrystallization temperature of artemether but they had no noticeable effect on the melting point of artesunate. While cashew gum caused shifts of the peaks in the FTIR spectra of both drugs, prosopis gum caused reduction in the height of the peaks; but no new peak was formed in any of the interactions.

Conclusion: This work has shown that no new compound was formed from interactions of the two drugs with either of the two gums. Therefore, the two gums are compatible with the two artemisinin derivatives and could be investigated as delivery agents for these drugs.

Keywords: cashew gum, prosopis gum, artemether, artesunate, compatibility.

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